Dantrolene sodium salt

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What is the Dantrolene sodium salt ?

Dantrolene sodium salt is COA, while it's Molecular Formula is C14H9N4O5Na. Dantrolene Sodium Salt is a skeletal muscle relaxant, which inhibits intracellular Ca 2+release from the sarcoplasmic reticulum.

What is the CAS number for Dantrolene sodium salt ?

The CAS number of Dantrolene sodium salt is 14663-23-1.

More information of Dantrolene sodium salt 14663-23-1 are:

Synonyms

2,4-Imidazolidinedione,1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt (9CI);Hydantoin, 1-[[5-(p-nitrophenyl)furfurylidene]amino]-, sodium salt (8CI);Dantrium;Dantrolene sodium;F 440;Sodium dantrolene;

CAS?Number

14663-23-1

Molecular Formula

C14H9N4O5Na

Molecular Weight

336.239

Boiling Point

85°C 4mm

Flash Point

283.1oC

HS CODE

2934999090

PSA

127.05000

LogP

1.71410

What is Dantrolene sodium salt (14663-23-1) used for?

Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 μM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 μM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 μM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 μg/ml) and MHS pigs (ED50 = 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.

InChI:InChI=1/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/b15-7+;

Articles related to Dantrolene sodium salt:

Article

Source

SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF DANTROLENE AND SODIUM DANTROLENE

Oleinik, A. F.,Andreeva, N. I.,Syubaev, R. D.,Golovina, S. M.,Vozyakova, T. I.

, p. 310 - 312 (2007/10/02)

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