What is the URIC ACID SODIUM SALT?

URIC ACID SODIUM SALT is solid /WHITE TO WHITE WITH YELLOW CAST POWDER, while it's Molecular Formula is C5H4 N4 O3 . Na. solid /WHITE TO WHITE WITH YELLOW CAST POWDER Uric acid sodium salt has been used in isotonic solution of NaCl dose titration study. It has been used as a suspension in NaCl for intra-articular administration to experimental animals to induce synovitis.

What is the CAS number for URIC ACID SODIUM SALT?

The CAS number of URIC ACID SODIUM SALT is 1198-77-2.

What is URIC ACID SODIUM SALT (1198-77-2) used for?

Uric acid is a ubiquitous end product of purine metabolism in humans that is mainly excreted in urine, whereas in other mammals it is further metabolized to allantoin by uricase. The final two steps in its production are catalyzed by xanthine oxidase, which generates superoxide. Uric acid acts as a potent peroxynitrite scavenger and antioxidant. However, high levels of serum uric acid (>120 µg/ml), termed hyperuricemia, are associated with gout, kidney stones, metabolic syndrome, hypertension, renal disease, and cardiovascular disease. Uric acid in the form of monosodium urate crystals has been proposed to trigger interleukin-1ß-mediated inflammation by activating the NOD-like receptor protein 3 inflammasome.InChI:InChI=1/C5H4N4O3.Na/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;/h(H4,6,7,8,9,10,11,12);

What is the URIC ACID SODIUM SALT?

URIC ACID SODIUM SALT is solid /WHITE TO WHITE WITH YELLOW CAST POWDER, while it's Molecular Formula is C5H4 N4 O3 . Na. solid /WHITE TO WHITE WITH YELLOW CAST POWDER Uric acid sodium salt has been used in isotonic solution of NaCl dose titration study. It has been used as a suspension in NaCl for intra-articular administration to experimental animals to induce synovitis.

What is the CAS number for URIC ACID SODIUM SALT?

The CAS number of URIC ACID SODIUM SALT is 1198-77-2.

What is URIC ACID SODIUM SALT (1198-77-2) used for?

Uric acid is a ubiquitous end product of purine metabolism in humans that is mainly excreted in urine, whereas in other mammals it is further metabolized to allantoin by uricase. The final two steps in its production are catalyzed by xanthine oxidase, which generates superoxide. Uric acid acts as a potent peroxynitrite scavenger and antioxidant. However, high levels of serum uric acid (>120 μg/ml), termed hyperuricemia, are associated with gout, kidney stones, metabolic syndrome, hypertension, renal disease, and cardiovascular disease. Uric acid in the form of monosodium urate crystals has been proposed to trigger interleukin-1β-mediated inflammation by activating the NOD-like receptor protein 3 inflammasome.InChI:InChI=1/C5H4N4O3.Na/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;/h(H4,6,7,8,9,10,11,12);

URIC ACID SODIUM SALT

URIC ACID SODIUM SALT GMP Manufacturer Global Trade 1198-77-2 with Fast Delivery

Molecular Formula: C5H4 N4 O3 . Na
Molecular Weight: 190.094
Appearance/Colour: solid /WHITE TO WHITE WITH YELLOW CAST POWDER
Boiling Point: °Cat760mmHg
Flash Point: °C
PSA： 117.46000
Density: g/cm³
LogP: -0.91670

URIC ACID SODIUM SALT(Cas 1198-77-2) Usage

Biochem/physiol Actions	Sodium urate is the sodium salt of uric acid. In gout, it is observed in synovial fluid. Sodium urate has been shown to precipitate calcium oxalate from urine. It is also known to reverse the inhibitory effects of reactive oxygen and nitrogen metabolites on gelatinase A activity. Excess sodium urate in soft tissues results in a condition referred to as tophi.
Safety Profile	Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

InChI:InChI=1/C5H4N4O3.Na/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;/h(H4,6,7,8,9,10,11,12);

1198-77-2 Relevant articles

Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model

Jiang, Yan,Lin, Yan,Hu, Yi-Juan,Song, Xiao-Jun,Pan, Hong-Hua,Zhang, Hong-Jian

, (2017)

Background: The Gnaphalium pensylvanicum...

Evaluation of Antioxidant Activity and Histopathological Changes Occurred by the Oral Ingestion of CuO Nanoparticles in Monosodium Urate Crystal-Induced Hyperuricemic BALB/c Mice

Kiyani, Mubin Mustafa,Butt, Maisra Azhar,Rehman, Hamza,Mustafa, Moheen,Sajjad, Abdul Ghafoor,Shah, Syed Sajid Hussain,Mahmood, Tariq,Bokhari, Syed Ali Imran

, p. 217 - 227 (2022)

Nanotechnology is an intensive branch of...

Arctium minus crude extract presents antinociceptive effect in a mice acute gout attack model

Fischer, Susana Paula Moreira,Brusco, Indiara,Camponogara, Camila,Piana, Mariana,Faccin, Henrique,Gobo, Luciana Assis,de Carvalho, Leandro Machado,Oliveira, Sara Marchesan

, p. 505 - 519 (2018)

Abstract: Gout is a disorder that trigge...

Treatment of gout

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Page/Page column 23, (2016/08/29)

Sodium 2-(5-bromo-4-(4-cyclopropyl-napht...

1198-77-2 Process route

: 69-93-2
uric Acid

: 1198-77-2
monosodium urate crystal

Conditions

Conditions	Yield
With sodium hydroxide; at 70 ℃; for 24h; pH=8-9;
With sodium hydroxide; In water; pH=8.9; Heating;
With sodium hydroxide; In water; at 60 ℃; pH=8.9;
With sodium hydroxide; at 70 ℃;